Collaborative research is crucial for advancing the understanding and treatment of Temporomandibular Disorders (TMDs) because it brings together diverse expertise and resources from various disciplines. By integrating efforts from different research groups, the TMD-PRIME registry can leverage a wide range of perspectives and methodologies, facilitating the rapid translation of basic research findings into practical, personalized therapies. This collaboration enhances the ability to develop targeted treatments and fosters the sharing of knowledge and techniques, ultimately accelerating the pace of discovery and improving patient outcomes.